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Genomic Technologies in Clinical Diagnostics: Molecular Techniques

September 16 2019 - September 17 2019

Genomic Technologies in Clinical Diagnostics: Molecular Techniques

 

Learn how molecular genetic techniques are used to identify the genetic factors that contribute to the development of disease.

Join this free online course here!

 

Why join the course?

Powerful new technologies have been driving forward immense and exciting changes in clinical practice.

The days of peering down the microscope to detect chromosome abnormalities are gone, replaced by chromosome analysis at the genomic level. Invasive Down syndrome tests in pregnancy have made way for the evaluation of fetal DNA in maternal blood. And instead of laborious gene-by-gene targeted sequencing, we can now sequence all of our genes in parallel in a single experiment.

The course has been approved for distance-learning continuing professional development (CPD) by the Royal College of Pathologists (RCPath): for 15 CPD credits.

 

Understand and apply molecular genetic techniques

This postgraduate-level course, in combination with Genomic Technologies in Clinical Diagnostics: Next Generation Sequencing Technologies, will help you understand these new and established genetic technologies, and their application to clinical practice.

This course focuses on molecular techniques. By the end, you will be able to demonstrate knowledge and applicability of the molecular principles behind:

  • array comparative genomic hybridisation (array CGH);
  • karyotyping;
  • fluorescent in situ hybridisation (FISH);
  • Southern blotting;
  • multiplex ligation probe amplification (MLPA);
  • polymerase chain reaction (PCR) and Sanger sequencing;
  • quantitative fluorescent PCR (QF-PCR);
  • single nucleotide polymorphism (SNP) genotyping and genome wide association studies (GWAS);
  • and the extraction and analysis of cell free fetal DNA, including non-invasive prenatal testing (NIPT).

Through practice exercises each week, you will evaluate which laboratory investigations are most suitable for a given clinical scenario.

 

What topics will you cover?

  • Polymerase chain reaction (PCR)
  • Sanger sequencing
  • Southern blotting
  • Multiplex ligation probe amplification (MLPA)
  • Array comparative genomic hybridisation (array CGH)
  • Karyotyping
  • Fluorescent in situ hybridisation (FISH)
  • Quantitative fluorescent PCR (QF-PCR)
  • Single nucleotide polymorphism (SNP) genotyping and genome wide association studies (GWAS)
  • The extraction and analysis of cell free fetal DNA, including non-invasive prenatal testing (NIPT).

Details

Start:
September 16 2019
End:
September 17 2019
Event Category:
Event Tags:
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Website:
https://www.futurelearn.com/courses/molecular-techniques

Venue

United Kingdom

Organiser

With any Whole Genome Sequencing (WGS) test ordered, a Record of Discussion (RoD) form will also need to be submitted. This document is to record the patient’s consent for genomic testing and their choice on taking part in research. Guidance on the patient choice conversation can be found here
 
This RoD form will be available for clinicians to download from this webpage. Once completed with the patient, it can be send to the lab with the corresponding test order form and sample.
Tests available to order will be listed in the National Genomic Test Directory. A test order form will soon be made available for clinicians on this webpage to download and complete. This form will include the address of the laboratory that the appropriate sample and completed form needs to be sent to.

Until the new Genomic Laboratory Service goes live, please continue to follow existing test order processes.
 
From April 2019 the interactive test ordering tool will be integrated into the National Genomics Informatics System (NGIS) and clinicians will be able to directly order tests online.